New Super Mario Brothers sucked pretty hard. The 4 player capabilities is about all that's gotten my interest as far as that game goes.
Super Mario Galaxy 2 should be fun. As met said, SMG was good, more SMG will probably be pretty OK times.
New Ico studio game is yes, but they also released a trailer last week so...
New Metriod, now. That's actually got me excited. MP3 was a good deal more fun than 2, but the series is in a desperate need of a second reboot. Lol phazon Dark Samus lol is old already. Kind of hard to tell what sort of game it is from the trailer, though. Part of it looked beat-em-up, part of it looked Ninja Gaideny, part of it looked Metroid Primey. It may not really resemble classic Metroid, but my response to that is a resounding "Who gives a fuck?"
Everything else... eh. MMOs, crappy series gets a third installment. Yawn. You get credit, E3, but only if the class fulfills a core curriculum requirement. If it's for your major, I would suggest thinking about switching degrees.
EDIT: Oh, yeah, there's one thing that caught my attention in a bad way:
L4D2. What the fuck, Valve. L4D was released in 2008. Late 2008. A little more than half a year ago.
By contrast, Half Life 2, Episode 2 was released in 2007.
We are getting HL2E3 AFTER we get L4D2.
Fuck you Valve.