Job A, where I currently work, is as a marketing department assistant for an educational textbook company. I've ranted about this job before, but it's in an area I care about (education) doing something that sometimes requires my skills (writing). The pay is pretty much terrible, though I can survive pretty well on it.
Job B, this potential dilemma opportunity, is as a customer service rep/troubleshooting agent at a financial software company. The pay is 1.65x what I currently make, which would be an enormous leap in income. The skills would probably be useful - VB, SQL, financial industry - but not in anything I care to do long-term.
Neither job contributes directly to my long-term goal, which is not surprising. The long-term goal is to return to academics, teach English in college/high school. Job B provides me flexibility I flat out won't and don't have at Job A. Job B has 1 week more vacation time, night shift premiums (work 24 hours and get paid at the 40 hour rate), and, of course, a significantly higher salary. With those, I can do independent research, travel to academic conferences, and study my languages and the GRE exams.
Practically speaking, Job B is mighty tempting. I am just fighting this stupid loyalty complex with Job A. That, and Job B is even -further- removed from my long-term goals and sets me down a path that, if I don't end up going to grad school, is in danger of dead-ending very quickly.